Computational scientist with expertise in the development of Parallel and Hybrid model computer codes for application to chemical, life and biomedical sciences. Research is balanced between development of life science software and its application to biomedical projects where more recently the biomedical application has been cancer. Scientific interests are focused on the roles that carbohydrates play in biological processes. A demonstration of the application of computational expertise is his use of molecular modelling simulations to develop therapeutics for cancer as well as his use of data analytics and informatics methods to develop diagnostics and prognostics for cancer.
Research focuses on the molecular genetic changes in oesophageal cancer using a whole genome sequencing approach to identify mutation signatures, epigenetic changes, gene mutation, deletions and insertions with specific relevance to early diagnosis and targeted therapeutic interventions in cancer.
Is one of the very rare cardiologists in South Africa who is clinically active and trained in fundamental molecular laboratory methods, combining laboratory and epidemiological skills.
Widely published in both local and international journals and books of various topics related to cardiovascular medicine. Internationally recognized for her outstanding work in the area of heart failure. Collaborations with a range of prestigious national and international clinical and academic centers. She holds an appointment as adjunct professor at the University of Queensland, Brisbane, Australia and as a visiting professor at the Baker Institute in Melbourne, Australia.
The Brain and Behaviour Initiative BBI enables cross-faculty, multidisciplinary, collaborative research in the cognitive and affective neurosciences and brings together expertise on phenotyping, genotyping, cognotyping, brain imaging and molecular signatures to address brain-behaviour issues.
New experimental techniques including brain imaging, genetic testing and neuropsychological assessment combined with new theoretical insights have opened up significant potential for the advancement of novel diagnostic tools and treatments for people with mental disorders. The initial focus on trauma and resilience has now extended to work in substance use and NeuroHIV. Her research focuses on child lung health including HIV-associated lung disease, childhood pneumonia and childhood TB. In she received the World Lung Health Award, awarded by the American Thoracic Society at a ceremony in San Diego, in recognition of work that has "the potential to eliminate gender, racial, ethnic, or economic health disparities worldwide".
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